Isotretinoin (Accutane) - Side Effects That Need Medical Monitoring By Your Physician

Isotretinion (accutane) is a very controversial drug with supporters who say that the drug has literally changed their lives, and with detractors demonizing the drug as an extremely dangerous drug. A simple search on the internet will quickly expose readers to all sorts of views on it from one extreme to the other.

What is not controversial is that isotretinoin is a powerful drug with an extremely potent effect, and one that can have very serious side-effects. In all cases, a doctor will require regular testing, usually involving blood work to ensure your safety.

The serious side-effects can be roughly divided into these categories.

Pregnancy

Isotretinion is teratogenic-it causes serious fetal abnormalities
This drug cannot under any circumstance be taken during pregnancy, and 1 month prior to and following pregnancy.
Pregnancy prevention programs are offered, and participation is likely a requirement for taking this drug.
A doctor must be consulted.

Bones

Hyperstosis and osteophytes (bony spurns) may develop, but are rarely of any consequence
Bone thinning (osteoporosis) is a possible risk
Premature close of bony epiphyses may occur in children, reducing long bone growth

Lipids

Cholestorol and triglyceride levels may increase; this should be followed by your doctor
Pancreatitis is a minor risk

Liver

May be mildly irritating to the liver
Liver abnormalities are relatively rare, but should be monitored

Neurologic

Pseudotumors in the cerebrum can occur, causing increased brain fluid pressure, headaches, vomiting, and visual disturbances.
Depression and suicidal thoughts have been reported in some patients causing controversy, but causal connections have yet to be conclusive.
Headaches may occur.

Musculoskeletal

Inflammation around the joints and tendonitis
Aches and pains around the joints and lower back pain are relatively common
These effects are temporary and can be minimized by use of anti-inflammatory medications

Blood

Leukopenia (reduced ability to produce white blood cells) may occur, but this is rare